Longevity Research & Guides
Evidence-based deep dives on supplements, protocols, and the science of healthy aging.
CoQ10, PQQ, and NMN: Comparing the Three Pillars of Mitochondrial Support
Mitochondrial decline is a hallmark of aging, but the supplements targeting it work through genuinely different mechanisms. Here's a side-by-side look at how CoQ10, PQQ, and NMN each address a different piece of the puzzle.
Intermittent Fasting and Autophagy: Where Supplements Fit In
Fasting is one of the most well-studied ways to trigger autophagy naturally. Here's how it works, and which supplements are studied as complements to — not replacements for — a fasting practice.
Building a Senolytic Stack: How Fisetin and Quercetin Work Together
Senolytics represent one of the newest categories in longevity science — compounds that selectively clear aged, dysfunctional cells. Here's a practical look at how fisetin and quercetin complement each other and how researchers approach dosing.
Quercetin: From Seasonal Allergies to Senolytic Research
Quercetin has one of the broadest evidence bases of any flavonoid, spanning allergy relief, cardiovascular health, and senolytic activity. Here's a complete look at what the research supports.
Alpha Lipoic Acid: The Antioxidant That Recycles Other Antioxidants
Alpha lipoic acid is unusual among antioxidants for its ability to regenerate vitamin C, vitamin E, and glutathione after they've been depleted. Here's the evidence behind this "universal antioxidant" and its role in blood sugar and nerve health.
PQQ: The Compound That Grows New Mitochondria
While most mitochondrial supplements support existing mitochondria, PQQ is one of the few compounds shown to stimulate the creation of entirely new ones. Here's the evidence behind this distinct mechanism.
Astaxanthin: The Antioxidant Behind Salmon's Color and Its Human Health Evidence
Astaxanthin is one of the most potent antioxidants found in nature, with a growing evidence base for skin health, eye protection, and exercise recovery. Here's what the research actually shows.
Pterostilbene: Resveratrol's More Bioavailable Cousin
Pterostilbene shares resveratrol's core mechanisms but with dramatically better absorption and a longer half-life. Here's how the two compare and what the evidence shows for this less-famous but pharmacologically superior polyphenol.
GlyNAC: The Baylor Protocol That Improved 9 Hallmarks of Aging
A combination of two cheap, well-studied amino acids reversed multiple biomarkers of aging in a clinical trial — improving muscle strength, cognition, and inflammation simultaneously. Here's the science behind GlyNAC.
Fisetin: The Senolytic Compound Backed by the Mayo Clinic
Fisetin has emerged as one of the most promising senolytic compounds in longevity research, with Mayo Clinic-led human trials now underway. Here's what separates it from other senolytics and what the evidence shows.
Lithium Orotate: Microdose Lithium for Mood and Neuroprotection
At doses roughly 100 times lower than prescription lithium, lithium orotate is being studied for neuroprotection, mood stability, and even Alzheimer's prevention. Here's what the evidence actually supports.
Apigenin and NAD+ Metabolism: A Supplement You've Probably Overlooked
Apigenin inhibits CD38, an enzyme that consumes 60% of the body's NAD+. It may be one of the most cost-effective ways to raise NAD+ levels — and it has additional anti-inflammatory and anti-cancer evidence.
Lion's Mane Mushroom: The Neurotrophic Evidence and What It Means for Brain Aging
Lion's Mane is the only known food source that stimulates nerve growth factor production in humans. Here's what the clinical research shows about cognitive function, nerve regeneration, and mood.
NAC and Glutathione: Why Your Body's Master Antioxidant Declines With Age
NAC is the most effective way to raise glutathione levels — and glutathione decline is now understood as a major driver of aging. Here's what the evidence shows and why this supplement deserves more attention.
Spermidine and Autophagy: The Longevity Mechanism You Haven't Heard Enough About
Spermidine is one of the few supplements that directly induces autophagy — the cellular cleanup process that declines with age and is strongly linked to longevity. Here's the evidence and what it means for supplementation.
Glycine: The Simplest Amino Acid With Surprisingly Deep Longevity Evidence
Glycine extends lifespan in multiple organisms, supports collagen and glutathione production, improves sleep quality, and costs almost nothing. The science behind one of the most overlooked longevity supplements.
Vitamin D3 and K2: Why You Need Both and How They Work Together
Vitamin D3 and K2 are rarely discussed together, but the science suggests they should be taken as a pair. Discover how they complement each other for bone density, cardiovascular health, and immune function.
Taurine and Longevity: Why This Underrated Amino Acid Is Getting Serious Attention
A 2023 study in Science found that taurine deficiency drives aging in multiple organisms — and that supplementation extended lifespan and healthspan. Here is what we know and what remains uncertain.
Omega-3 Fatty Acids and Longevity: EPA, DHA, and What the Research Shows
Omega-3s are among the most studied supplements in medicine. Beyond cardiovascular benefits, emerging research on telomeres, inflammation, and brain aging makes a compelling case for their role in longevity.
Creatine Is Not Just for Gym-Goers: The Brain and Longevity Evidence
Creatine is best known as a muscle supplement, but emerging research shows significant benefits for brain energy, cognitive aging, depression, and even sleep deprivation. The evidence is stronger than most people realize.
CoQ10: Ubiquinol vs Ubiquinone and Why the Form Matters
CoQ10 is sold in two forms — ubiquinone and ubiquinol — at very different price points. The science on which is better absorbed and who actually needs the more expensive form might surprise you.
Senolytics Explained: Quercetin, Fisetin, and Clearing Zombie Cells
Senescent cells accumulate with age and drive inflammation and disease. A new class of compounds called senolytics can selectively eliminate them. Here is what the research shows about quercetin and fisetin.
Magnesium L-Threonate and Brain Health: The Evidence
Of the many forms of magnesium, only L-threonate has been shown to cross the blood-brain barrier in meaningful amounts. Here's what the research shows about memory, sleep, and cognitive aging.
Berberine vs Metformin: A Longevity Perspective
Berberine has been called 'nature's Metformin.' Both activate AMPK and improve blood sugar, but they work differently and suit different people. Here's what the evidence shows.
NMN Supplementation: What the Science Actually Says
NMN has become one of the most talked-about longevity supplements, but does the research support the hype? We review the human trials, optimal dosing, and what to look for when buying.